Xu, X.*, Olivas, N.D., Levi, R., Ikrar, T., Nenadic, Z. (2010) High resolution and fast functional mapping of cortical circuitry through a novel combination of voltage sensitive dye imaging and laser scanning photostimulation. Journal of Neurophysiology 103, 2301 – 2312. * Senior and corresponding author
Shi, Y., Nenadic, Z., Xu, X. (2010) Novel use of matched filtering for synaptic event detection and extraction. PLoS ONE 5(11): e15517. doi:10.1371/journal.pone.0015517.
Xu, X. (2011) High precision and fast functional mapping of brain circuitry through laser scanning photostimulation and fast dye imaging. In: Laser scanning, theory and applications (Wang C-C, ed), pp 113-132. Rijeka, Croatia: InTech.
Ikrar, T., Olivas, N., Shi, Y., Xu, X. (2011) Mapping inhibitory neuronal circuits by laser scanning photostimulation. Journal of Visualized Experiments (56), e3109, DOI : 10.3791/3109. [PMID:22006064]
Ikrar, T., Shi, Y., Velasquez, T, Goulding, M. and Xu, X.(2012) Cell-type specific regulation of cortical excitability through the allatostatin receptor system. Frontiers in Neural Circuits 6:2. doi:10.3389/fncir.2012.00002 [PMCID: PMC3262160]
Li Y, Aimone, J.B., Xu, X., Callaway, E.M., Gage, F.H. (2012) Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network.Proceedings of National Academy of Sciences USA, 109: 4290-4295.
Olivas, N.D., Quintanar-Zilinskas, V., Nenadic, Z., Xu, X. (2012) Laminar circuit organization and response modulation in mouse visual cortex. Frontiers in Neural Circuits 6:70. doi: 10.3389/fncir.2012.00070 [PMCID: PMC3464489]
Clement, J.P., Aceti, M., Creson, T.K., Ozkan, E.D., Shi, Y., Reish, N.J., Almonte, A.G., Miller, B.H., Wiltgen, B.J., Miller, C.A., Xu, X., Rumbaugh, G. (2012) Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses. Cell 151:709-723. [PMID: 23141534]
Ahrar, S., Nguyen, T.V., Shi, Y., Thomas, P.V., Ikrar, T., Xu, X.*, Hui, E.E.* (2013) Optical stimulation and imaging of functional brain circuitry in a laminar flow chamber. Lab Chip 13:536-41. [PMID: 23044655] * Co-corresponding Authors
Haettig, J.#, Sun, Y.#, Wood, M.A.*, Xu, X*. (2013) Cell-type specific inactivation of hippocampal CA1 disrupts location-dependent object recognition in the mouse. Learning & Memory 20:139-146. [PMID: 23418393] #Co-first authors; * Co-corresponding Authors
Kuhlman, S.J. #, Olivas, N.D. #, Tring, E., Ikrar, T., Xu, X.*, Trachtenberg, J.T.* (2013) A disinhibitory microcircuit initiates critical period plasticity in visual cortex. Nature (Advanced Online Publication): August 2013. DOI: 10.1038/nature12485. #Co-first authors; * Co-corresponding Authors
San Antonio, A., Liban, K., Ikrar, T., Tsyganovskiy, E., Xu, X. (2013). Distinct physiological and developmental properties of hippocampal CA2 subfield revealed using anti-Purkinje cell protein 4 (PCP4) immunostaining. Journal of Comparative Neurology. 2013 Oct 25. doi: 10.1002/cne.23486. [Epub ahead of print].
Ikrar, T., Guo, N., He, K., Besnard, A., Levinson, S., Hill, A., Lee, H., Hen, R., Xu, X.*, Sahay, A. * Adult neurogenesis modifies excitability of the dentate gyrus. Frontiers in Neural Circuits, 26 December 2013 | doi: 10.3389/fncir.2013.00204. * Co-corresponding Authors
Y.Shi, T.Ikrar, N.D.Olivas, and X.Xu (2013) Bi-directional global spontaneous network activity immediately precedes the canonical unidirectional circuit organization in the developing hippocampus. Journal of Comparative Neurology 2013 Dec 20. doi: 10.1002/cne.23528. [Epub ahead of print]
Sun, Y., Nguyen, A., Nguyen, J., Le, L., Saur, D., Choi, J., Callaway, E.M., Xu, X. (2014) Cell-type specific circuit connectivity of hippocampal CA1 revealed through Cre-dependent rabies tracing. Cell Reports Cell Rep. 2014 Apr 10;7(1):269-80. doi: 10.1016/j.celrep.2014.02.030. Epub 2014 Mar 20.
Parks, G. #, Olivas, N.D. #, Ikrar, T. #, Sanathara, N., Wang, L., Wang, Z., Civelli, O. *, Xu, X. * (2014) Histamine inhibits the melanin-concentrating hormone system: Implications for sleep and arousal. Journal of Physiology (http://jp.physoc.org/content/early/2014/03/17/jphysiol.2013.268771.long ) (J Physiol. 2014 Mar 17. [Epub ahead of print]). # Co-first authors; * Co-corresponding Authors
Shi, Y., Veidenbaum, A., Nicolau, A., Xu, X. (2014) Large scale neural circuit mapping data analysis accelerated with the graphical processing unit (GPU). Journal of Neuroscience Methods 2014 Sep 30. pii: S0165-0270(14)00347-1. doi: 10.1016/j.jneumeth.2014.09.022. [Epub ahead of print]
Nguyen AQ, Dela Cruz JA, Sun Y, Holmes TC, Xu X. Genetic cell targeting uncovers specific neuronal types and distinct subregions in the bed nucleus of the stria terminalis. J Comp Neurol. 2015 Dec 30; PubMed PMID: 26718312.
Xu X, Olivas ND, Ikrar T, Peng T, Holmes TC, Nie Q, Shi Y. Primary visual cortex shows laminar-specific and balanced circuit organization of excitatory and inhibitory synaptic connectivity. J Physiol. 2016 Apr 1;594 (7):1891-910. PubMed PMID: 26844927.
Xu X, Ikrar T, Sun Y, Santos R, Holmes, TC, Francesconi W, Berton, F. High-resolution and cell-type-specific photostimulation mapping shows weak excitatory versus strong inhibitory inputs in the bed nucleus of the stria terminalis. J Neurophysiol. 2016, 115:3204-16. [PMID: 27052587]
Xu X, Sun Y, Holmes, TC, López A. Non-canonical connections between the subiculum and hippocampal CA1. J Comp Neurol. 2016, 524:3666-3673 [PMID: 27150503]
Baohan, A., Ikrar, T., Tring, E., Xu, X.*, Trachtenberg, T.* Pten and EphB4 regulate the establishment of perisomatic inhibition in mouse visual cortex. Nature Communications 2016 7:12829 doi: 10.1038/ncomms12829 * Co-corresponding Authors
Sun, Y., Ikrar, T., Davis, M.F., Gong, N., Zheng, X., Luo, Z.D., Lai, C., Mei, L., Holmes, T.C., Gandhi, S.P., Xu, X.* Neuregulin-1 / ErbB4 signaling regulates visual cortical plasticity. Neuron 92:160-173. http://dx.doi.org/10.1016/j.neuron.2016.08.033 [PMID: 27641496] * Corresponding Author
Stephany, C., Ikrar, T., Nguyen, C., Xu, X.*, McGee, A.W.* Nogo receptor 1 confines a dishinhibitory microcircuit to the critical period in visual cortex. J Neurosci. 2016, 36:11006-11012. * Co-corresponding Authors
Garcia-Junco-Clemente, P., Ikrar, T., Tring, E., Xu, X., Ringach, D.L. & Trachtenberg, J.T. An inhibitory pull-push circuit in frontal cortex Nature Neuroscience 2017, 20:389-392. doi: 10.1038/nn.4483. [PMID: 28114295]
Sun, Y., Grieco, S.F., Holmes, T.C., Xu, X. Local and long-range circuit connections to hilar mossy cells in the dentate gyrus. eNuro 2017 Apr 19; 4(2). pii: ENEURO.0097-17.2017. doi: 10.1523/ENEURO.0097-17.2017
Agarwal N., Xu X., Gopi M. (2017) Automatic Detection of Histological Artifacts in Mouse Brain Slice Images. In: Müller H. et al. (eds) Medical Computer Vision and Bayesian and Graphical Models for Biomedical Imaging. MCV 2016, BAMBI 2016. Lecture Notes in Computer Science, vol 10081. Springer, Cham
Alachkar, A., Wang, L., Yoshimura, R., Hamzeh, A.R., Wang, Z., Sanathara, N., Lee, S.M., Xu, X., Abbott, G.W., Civelli1, O. (2017) Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits. Molecular Psychiatry, advance online publication 15 August 2017; doi: 10.1038/mp.2017.164. [PMID: 28809400]
Chung, A.S., Miller, S.M., Sun, Y., Xu, X., Zweifel, L.S. (2017) Sexual congruency in the connectome and translatome of VTA dopamine neurons. Sci Rep. 2017 Sep 11;7(1):11120. doi: 10.1038/s41598-017-11478-5. [PMID: 28894175]
Sanathara, N.M., Garau, C., Alachkar, A., Wang, L., Wang, Z., Nishimori, K., Xu, X., Civelli, O. (2017) Melanin concentrating hormone modulates oxytocin-mediated marble burying. Neuropharmacology. 2017 Sep 6. pii: S0028-3908(17)30425-2. doi: 10.1016/j.neuropharm.2017.09.008. [Epub ahead of print] [PMID: 28888943]
Sun, Y., Nitz, D.A., Holmes, T.C., Xu, X. (2018) Opposing and complementary topographic connectivity gradients revealed by quantitative analysis of canonical and non-canonical hippocampal CA1 inputs. eNeuro DOI: https://doi.org/10.1523/ENEURO.0322-17.2018
Grieco, S.F., Holmes, T.H., Xu, X. (2018) Neuregulin directed molecular mechanisms of visual cortical plasticity. Journal of Comparative Neurology 2018 Feb 21. doi: 10.1002/cne.24414. [Epub ahead of print]
Lin, X., Itoga, C.A., Taha, S., Li, M.H., Chen, R., Sami, K., Berton, F., Francesconi, W., Xu, X. c-Fos mapping of brain regions activated by multi-modal and electric foot shock stress. Neurobiology of Stress https://doi.org/10.1016/j.ynstr.2018.02.001
Agarwal N., Xu X., Gopi M. (2018) Geometry processing of conventionally produced mouse brain slice images. Journal of Neuroscience Methods 306:45-56. doi: 10.1016/j.jneumeth.2018.04.008. Epub 2018 Apr 22.
Antoine Besnard, Yuan Gao, Michael TaeWoo Kim, Hannah Twarkowski, Alexander Keith Reed, Tomer Langberg, Wendy Feng, Xiangmin Xu, Dieter Saur, Larry S. Zweifel, Ian Davison & Amar Sahay (2019). Dorsolateral septum somatostatin interneurons gate mobility to calibrate context-specific behavioral fear responses. Nat Neurosci. 2019 Mar;22(3):436-446. doi: 10.1038/s41593-018-0330-y. Epub 2019 Feb 4.
Yulin Shi*, Steven Grieco*, Todd Holmes, and Xiangmin Xu (2019) Development of local circuit connections to hilar mossy cells in the mouse dentate gyrus. eNeuro 7 March 2019, ENEURO.0370-18.2019; DOI: https://doi.org/10.1523/ENEURO.0370-18.2019
Christy Itoga, Yuncai Chen, Cameron Fateri, Paula Echeverry, Jennifer Lai, Jasmine Delgado, Shapatur Badhon, Annabel Short, Tallie Z. Baram*, Xiangmin Xu*. (2019) New Viral-Genetic Mapping Uncovers an Enrichment of Corticotropin-Releasing Hormone-Expressing Neuronal Inputs to the Nucleus Accumbens from Stress-Related Brain Regions. Journal of Comparative Neurology 2019 Mar 12. doi: 10.1002/cne.24676. [Epub ahead of print]
Lazaro MT, Taxidis J, Shuman T, Bachmutsky I, Ikrar T, Santos R, Marcello GM, Mylavarapu A, Chandra S, Foreman A, Goli R, Tran D, Sharma N, Azhdam M, Dong H, Choe KY, Peñagarikano O, Masmanidis SC, Rácz B, Xu X, Geschwind DH, Golshani P. (2019) Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism. Cell Reports 2019 May 28;27(9):2567-2578.e6. doi: 10.1016/j.celrep.2019.05.006. [PMID: 31141683]
Yanjun Sun, Suoqin Jin, Xiaoxiao Lin, Lujia Chen, Xin Qiao, Li Jiang, Pengcheng Zhou, Kevin G. Johnston, Peyman Golshani, Qing Nie, Todd C. Holmes, Douglas A. Nitz*, Xiangmin Xu* (2019) CA1-projecting Subiculum Neurons Facilitate Object-Place Learning. Nature Neuroscience https://www.nature.com/articles/s41593-019-0496-y https://rdcu.be/bRIhc
Grieco, Steven; Wang, Gina; Mahapatra, Ananya; Lai, Cary; Holmes, Todd; Xu, Xiangmin (2019) Neuregulin and ErbB expression is regulated by development and sensory experience in mouse visual cortex. Journal of Comparative Neurology Aug 27. doi: 10.1002/cne.24762. [Epub ahead of print]
Nian Gong, Garo Hagopian, Todd C. Holmes, Z. David Luo*, and Xiangmin Xu* (2019) Functional Reorganization of Local Circuit Connectivity in Superficial Spinal Dorsal Horn with Neuropathic Pain States. eNeuro 2019 Sep 18. pii: ENEURO.0272-19.2019. doi: 10.1523/ENEURO.0272-19.2019. [Epub ahead of print]
Guo, Zhi-Ling #; Lin, Xiaoxiao; Samaniego, Tracy; Isreb, Alexander; Cao, Stacey; Malik, Shaista; Holmes, Todd; Xu, Xiangmin # (2019) Fos-CreER Based Genetic Mapping of Forebrain Regions Activated by Acupuncture. Journal of Comparative Neurology 2019 Oct 10. doi: 10.1002/cne.24789. [Epub ahead of print]
Michael G Frantz, Emily C Crouse, Guela Sokhadze, Taruna Ikrar, Céleste-Élise Stephany, Collins Nguyen, Xiangmin Xu*, Aaron W McGee* (2020) Layer 4 gates experience-dependent plasticity in visual cortex independent of a canonical microcircuit. Current Biology, August 3, 2020 https://doi.org/10.1016/j.cub.2020.05.067 * Co-corresponding Authors
Xiangmin Xu, Todd C. Holmes, Min-Hua Luo, Kevin T. Beier, Gregory D. Horwitz, Fei Zhao, Wenbo Zeng, May Hui, Bert L. Semler, Rozanne M. Sandri-Goldin (2020) Viral vectors for neural circuit mapping and recent advances in trans-synaptic anterograde tracers. Neuron (PRIMER review article) https://doi.org/10.1016/j.neuron.2020.07.010
Yang, H., Xiong, F., Song, Y.G., Jiang, H.F., Qin, H.B., Zhou, J., Lu, S., Grieco, S.F., Xu, X., Zeng, W.B., Zhao, F., Luo, M-H. (2020) HSV-1 H129-Derived Anterograde Neural Circuit Tracers: Improvements, Production and Applications. 2020 Dec 24. doi: 10.1007/s12264-020-00614-3. PMID: 33367996
Steven F Grieco, Xin Qiao, Xiaoting Zheng, Yongjun Liu, Lujia Chen, Hai Zhang, Zhaoxia Yu, Jeffrey Gavornik, Cary Lai, Sunil Gandhi, Todd C Holmes, Xiangmin Xu (2020) Subanesthetic ketamine reactivates adult cortical plasticity to restore vision from amblyopia. Current Biology (in press, accepted on 07/01/2020) https://doi.org/10.1016/j.cub.2020.07.008
Kevin G. Johnston, Steven F. Grieco, Zhaoxia Yu, Suoqin Jin, Tong Shen, Rachel Crary, John F. Guzowski, Todd C. Holmes, Qing Nie*, Xiangmin Xu* (2020) Robust Population Single Neuronal Calcium Signal Extraction Using SCOUT Allows for Longitudinal Analysis of Behavior-associated Neural Ensemble Dynamics. PLOS Computational Biology (submitted) https://www.biorxiv.org/content/10.1101/2020.08.26.268151v1.full
Yong-Jun Liu, Elizabeth Spangenberg, Bryan Tang, Todd C Holmes, Kim N Green, Xiangmin Xu. (2020) Microglia elimination increases neural circuit connectivity and activity in adult mouse cortex. J Neurosci. 2020 Dec 23; JN-RM-2140-20. doi: 10.1523/JNEUROSCI.2140-20.2020. Online ahead of print. PMID: 33380470
XiaoTing Zheng, Kirstie J. Salinas, Dario X. Figueroa Velez, Taylor Nakayama, Xiaoxiao Lin, Xiangmin Xu, Sunil P. Gandhi. (2021) Host Interneurons Mediate Cortical Plasticity Reactivated by Embryonic Inhibitory Cell Transplantation. Nature Communications 2021 Feb 8;12(1):862. doi: 10.1038/s41467-021-21097-4. PMID: 33558487.
Steven F. Grieco, Xin Qiao, Kevin Johnsto2, Lujia Che1, Renetta R. Nelson, Cary Lai, Todd C. Holmes, Xiangmin Xu (2021). Neuregulin signaling mediates the acute and sustained antidepressant effects of subanesthetic ketamine. Translational Psychiatry 2021 Feb 24;11(1):144. doi: 10.1038/s41398-021-01255-4. PMID: 33627623
Jennifer Wong, Steven Grieco, Karoni Dutt, Luija Chen, Jacquelyn Thelin, George Andrew Inglis, Shangrila Parvin, Sandra Garraway, Xiangmin Xu, Alan Goldin, and Andrew Escayg (2021). Autistic-like behavior, spontaneous seizures, and increased neuronal excitability in a Scn8a mouse model. Neuropsychopharmacolog https://www.nature.com/articles/s41386-021-00985-9
Jennifer Wong, Steven Grieco, Karoni Dutt, Luija Chen, Jacquelyn Thelin, George Andrew Inglis, Shangrila Parvin, Sandra Garraway, Xiangmin Xu, Alan Goldin, and Andrew Escayg (2021). Autistic-like behavior, spontaneous seizures, and increased neuronal excitability in a Scn8a mouse model. Neuropsychopharmacolog https://www.nature.com/articles/s41386-021-00985-9
Zhaoxia Yu#, Michele Guindani, Steven F. Grieco, Lujia Chen, Todd C. Holmes, Xiangmin Xu# (2021) Beyond t-Test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research. Neuron https://doi.org/10.1016/j.neuron.2021.10.030
Xiaoxiao Lin, Lujia Chen; David Baglietto-Vargas; Qiao Ye; Frank M LaFerla; Douglas A. Nitz; Todd C. Holmes; Xiangmin Xu (2021) Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer’s disease mouse model. Neurobiology of Disease https://doi.org/10.1016/j.nbd.2021.105562.
Xiaoxiao Lin, Michelle Amalraj, Crisylle Blanton, Brenda Avila, Todd C. Holmes, Douglas A. Nitz, Xiangmin Xu (2021) Noncanonical projections to the hippocampal CA3 regulate spatial learning and memory by modulating the feedforward hippocampal trisynaptic pathway. PLOS Biology 2021 Dec 20;19(12):e3001127. doi: 10.1371/journal.pbio.3001127.
Xiaoxiao Lin,, Lujia Chen, Amandine Jullienne, Arjang Salehi, Mary Hamer, Todd Holmes, Andre Obenaus*, Xiangmin Xu * (2022) Longitudinal dynamics of micro-vascular recovery after acquired cortical injury. Acta Neuropathologica Communications 10, 59 (2022). https://doi.org/10.1186/s40478-022-01361-4
Xu Chen, Riccardo Calandrelli, John Girardini, Zhangming Yan, Zhiqun Tan, Xiangmin Xu, Sheng Zhong (2022) PHGDH expression increases with progression of Alzheimer’s disease pathology and symptoms. Cell Metabolism 2022 May 3;34(5):651-653. doi: 10.1016/j.cmet.2022.02.008.
Kevin G. Johnston, S. F. G., Hai Zhang, Suoqin Jin, Xiangmin Xu*, Qing Nie*. racking Longitudinal Population Dynamics of Single Neuronal Calcium Signal Using SCOUT. Cell Reports Methods, doi:https://www.cell.com/cell-reports-methods/pdfExtended/S2667-2375(22)00065-0 (2022).
Ding Quan Ng; Daniella Chan; Parisa Agrawal; Weian Zhao; Xiangmin Xu; Munjal Acharya, Alexandre Chan (2022). Evidence of Brain-Derived Neurotrophic Factor in Ameliorating Cancer-Related Cognitive Impairment: A Systematic Review of Human Studies. Crit Rev Oncol Hematol. 2022 Jun 17;176:103748. doi: 10.1016/j.critrevonc.2022.103748. Online ahead of print.
Qiao Ye, Gocylen Gast, Xilin Su, Takashi Saito, Takaomi C. Saido, Todd C. Holmes, Xiangmin Xu (2022). Hippocampal neural circuit connectivity alterations in an Alzheimer’s disease mouse model revealed by monosynaptic rabies virus tracing. Neurobiol Dis. 2022 Jul 14;105820. doi: 10.1016/j.nbd.2022.105820. Online ahead of print.
Yanxiao Zhang*, Maria Luisa Amaral*, Chenxu Zhu, Steven F. Grieco, Xiaomeng Hou, Lin Lin, Justin Buchanan, Liqi Tong, Sebastian Preissl, Xiangmin Xu, Bing Ren. Single-cell Epigenome Analysis Reveals Age-associated Decay of Heterochromatin Domains in Excitatory Neurons in the Mouse Brain. Nature Cell Research, 2022. 32, 1008–1021 . PMCID: PMC9652396, DOI: 10.1038/s41422-022-00719-6
Grieco SF, Castrén E, Knudsen GM, Kwan AC, Olson DE, Zuo Y, Holmes TC, Xu X. Psychedelics and Neural Plasticity: Therapeutic Implications. J Neurosci. 2022 Nov 9;42(45):8439-8449. doi: 10.1523/JNEUROSCI.1121-22.2022. PMID: 36351821
Tan Z, Garduño BM, Aburto PF, Chen L, Ha N, Cogram P, Holmes TC, Xu X. Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer’s disease. Acta Neuropathol Commun. 2022 Dec 19;10(1):182. doi: 10.1186/s40478-022-01481-x. PMID: 36529803
Xiong F, Yang H, Song YG, Qin HB, Zhang QY, Huang X, Jing W, Deng M, Liu Y, Liu Z, Shen Y, Han Y, Lu Y, Xu X, Holmes TC, Luo M, Zhao F, Luo MH, Zeng WB. An HSV-1-H129 amplicon tracer system for rapid and efficient monosynaptic anterograde neural circuit tracing. Nat Commun. 2022 Dec 10;13(1):7645. doi: 10.1038/s41467-022-35355-6. PMID: 36496505
Sun Y, Zweifel LS, Holmes TC, Xu X. Whole-brain input mapping of the lateral versus medial anterodorsal bed nucleus of the stria terminalis in the mouse. Neurobiol Stress. 2023 Feb 15;23:100527. doi: 10.1016/j.ynstr.2023.100527. eCollection 2023 Mar. PMID: 36861029
Zhao W, Johnston KG, Ren H, Xu X, Nie Q. Inferring neuron-neuron communications from single-cell transcriptomics through NeuronChat. Nat Commun. 2023 Feb 28;14(1):1128. doi: 10.1038/s41467-023-36800-w. PMID: 36854676
Birnie MT, Short AK, de Carvalho GB, Taniguchi L, Gunn BG, Pham AL, Itoga CA, Xu X, Chen LY, Mahler SV, Chen Y, Baram TZ. Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice. Nat Commun. 2023 Feb 25;14(1):1088. doi: 10.1038/s41467-023-36780-x. PMID: 36841826
Zhang H, Chen L, Johnston KG, Crapser J, Green KN, Ha NM, Tenner AJ, Holmes TC, Nitz DA, Xu X. Degenerate mapping of environmental location presages deficits in object-location encoding and memory in the 5xFAD mouse model for Alzheimer’s disease. Neurobiol Dis. 2023 Jan;176:105939. doi: 10.1016/j.nbd.2022.105939. Epub 2022 Dec 1. PMID: 36462718
Grieco SF, Holmes TC, Xu X. Probing neural circuit mechanisms in Alzheimer’s disease using novel technologies. Mol Psychiatry. 2023 Mar 23. doi: 10.1038/s41380-023-02018-x. Online ahead of print. PMID: 36959497
Lujia Chen*, Xiaoxiao Lin*, Qiao Ye, Zoran Nenadic, Todd C. Holmes, Douglas A. Nitz#, Xiangmin Xu Hippocampal CA1 activity dynamics for environmental representation are anatomically organized. iScience Volume 26, Issue 5, 19 May 2023, 106703. https://doi.org/10.1016/j.isci.2023.106703.
Xiaoxiao Lin, Neeyaz Cyrus, Brenda Avila, Todd C. Holmes, Xiangmin Xu. Hippocampal CA3 inhibitory neurons receive extensive noncanonical synaptic inputs from CA1 and subicular complex. Journal of Comparative Neurology (First published: 13 June 2023) https://doi.org/10.1002/cne.25510.
Paff M, Grieco SF, Xu X. Obtaining brain tissue from living patients for psychiatry research: collaboration with patients with epilepsy and neurosurgeons. Lancet Psychiatry. 2023 Jun;10(6):381. doi: 10.1016/S2215-0366(23)00142-6. Epub 2023 Apr 21. PMID: 37088087.
Grieco SF, Johnston KG, Gao P, Garduño BM, Tang B, Yi E, Sun Y, Horwitz GD, Yu Z, Holmes TC, Xu X. Anatomical and molecular characterization of parvalbumin-cholecystokinin co-expressing inhibitory interneurons: implications for neuropsychiatric conditions. Mol Psychiatry. 2023 Jul 13. doi: 10.1038/s41380-023-02153-5.
Grieco SF, Holmes TC, Xu X. Meeting report for the 2023 UC Irvine Center for Neural Circuit Mapping Conference: structure, function and development of neural circuits. Mol Psychiatry. 2023 Nov 2. doi: 10.1038/s41380-023-02308-4. Epub ahead of print. PMID: 37919404.
Zhang H, Sumbria RK, Chang R, Sun J, Cribbs DH, Holmes TC, Fisher MJ, Xu X. Erythrocyte-brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo. J Neuroinflammation. 2023 Nov 15;20(1):265. doi: 10.1186/s12974-023-02932-5. PMID: 37968737; PMCID: PMC10647121.
Xin Qiao, Steven Grieco, Zhaoxia Yu, Todd Holmes, and Xiangmin Xu (2023) Intranasal Delivery of Ketamine Induces Cortical Disinhibition. eNeuro 2024 Jan 17;11(1):ENEURO.0107-23.2023. doi: 10.1523/ENEURO.0107-23.2023.
Alexis Bouin1#, Ginny Wu#, Orkide O. Koyuncu, Qiao Ye, Keun-Young Kim, Michele Wu, Liqi Tong, Lujia Chen, Sebastien Phan, Mason R. Mackey, Ranjan Ramachandra, Mark H. Ellisman, Todd C. Holmes, Bert L. Semler*, Xiangmin Xu* (2024) New rabies viral resources for multi-scale neural circuit mapping. Molecular Psychiatry Mol Psychiatry (2024). https://doi.org/10.1038/s41380-024-02451-6
Yanjun Sun, Douglas A. Nitz, Xiangmin Xu, Lisa M. Giocomo (2024) Subicular neurons encode concave and convex geometries. Nature (in press) https://doi.org/10.1038/s41586-024-07139-z
Usha Nekanti, Pooja Sakthivel, Atena Zahedi, Dana Creasman, Rebecca Nishi, Courtney Dumont, Katja Piltti, Glenn Guardamondo, Norbert Hernandez, Xingyuan Chen, Hui Song, Xiaoxiao Lin, Joshua Martinez, Lillian On, Anita Lakatos, Kiran Pawar, Brian David, Zhiling Guo, Stephanie Seidlits, Xiangmin Xu, Lonnie Shea, Brian Cummings, Aileen Anderson (2024) Multichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI. npj Regenerative Medicine (in press).
B. Maximiliano Garduño, Patrick Hanni, Chelsea Hays, Patricia Cogram, Nathan Insel*, Xiangmin Xu* (2024) How the Forebrain Transitions to Adulthood: Developmental Plasticity Markers in a Long-lived Rodent Reveal Region Diversity and the Uniqueness of Adolescence. Front. Neurosci. Sec. Neurodevelopment Volume 18 – 2024 | doi: 10.3389/fnins.2024.1365737
Patricia Cogram*, B. Maximiliano Garduño, Bing Ren, Xiangmin Xu* (2024) First International Conference on Unconventional Animal Models of Alzheimer’s Disease and Aging. Journal of Alzheimer’s Disease. 2024 Feb 20. doi: 10.3233/JAD-249004. Online ahead of print. PMID: 38393919 DOI: 10.3233/JAD-249004
Pan Gao, Matthew Xavier Rivera, Xiaoxiao Lin, Todd C Holme, Hu Zhao, Xiangmin Xu* (2024) Immunolabeling-compatible PEGASOS Tissue Clearing for High-resolution Whole Mouse Brain Imaging. Front. Neural Circuits, 17 April 2024 Volume 18 – 2024 | https://doi.org/10.3389/fncir.2024.1345692
Qiao Ye, Gocylen Gast, Erik George Wilfley, Hanh Huynh, Chelsea Hays, Todd C. Holmes, Xiangmin Xu*. (2024) Monosynaptic rabies tracing reveals sex- and age-dependent dorsal subiculum connectivity alterations in an Alzheimer’s disease mouse model. Journal of Neuroscience 17 April 2024, 44 (16) e1796232024; DOI: https://doi.org/10.1523/JNEUROSCI.1796-23.2024
Xinhe Zheng, Boli Wu, Yuejia Liu, Sean K. Simmons, Kwanho Kim, Grace S. Clarke, Abdullah Ashiq, Joshua Park, Jiwen Li, Zhilin Wang, Liqi Tong, Qizhao Wang, Keerthi T. Rajamani, Rodrigo Mun oz-Castaneda, Shang Mu, Tianbo Qi, Yunxiao Zhang, Zi Chao Ngiam, Naoto Ohte, Carina Hanashima, Zhuhao Wu, Xiangmin Xu, Joshua Z. Levin, and Xin Jin (2024) Massively parallel in vivo Perturb-seq reveals cell-type-specific transcriptional networks in cortical development. Cell 187, 1–13. June 20, 2024. https://doi.org/10.1016/j.cell.2024.04.050
Yunyan Ding, Yicong Huang, Pan Gao, Andy Thai, Atchuth Naveen Chilaparasetti, M Gopi, Xiangmin Xu and Chen Li (2024) Brain Image Data Processing Using Collaborative Data Workflows on Texera. Frontiers in Neural Circuits, 09 July 2024 Volume 18 – 2024 | https://doi.org/10.3389/fncir.2024.1398884.
Lujia Chen, Xiangduo Kong, Kevin Gregory Johnston, Ali Mortazavi, Todd C Holmes, Zhiqun Tan, Kyoko Yokomori, Xiangmin Xu* (2024) Single-Cell Spatial Transcriptomics Reveals a Dystrophic Trajectory Following a Developmental Bifurcation of FSHD Myoblast Cell Fates. Genome Research 2024 May 22:gr.278717.123. doi: 10.1101/gr.278717.123. Online ahead of print.2024.
Kevin G. Johnston, Bereket T. Berackey, Kristine Minh Tran, Alon Gelber, Zhaoxia Yu, Grant MacGregor, Eran A. Mukamel, Zhiqun Tan, Kim Green, Xiangmin Xu* (2024) Single cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2R47H Alzheimer’s risk gene mutation. Molecular Psychiatry https://doi.org/10.1038/s41380-024-02651-0.
Kevin G. Johnston, Steven F. Grieco, Qing Nie, Fabian J. Theis, Xiangmin Xu* (2024) Small Data Methods in Omics: The Power of One. Nat Methods. 2024 Sep;21(9):1597-1602. doi: 10.1038/s41592-024-02390-8. Epub 2024 Aug 22. PMID: 39174710.
Steven F Grieco, Todd C Holmes, Xiangmin Xu (2024) Meeting report for the 2024 UC Irvine Center for neural circuit mapping conference: Brain cell types, circuits, and disorders. Mol Psychiatry. 2024 Oct 9. doi: 10.1038/s41380-024-02775-3. Epub ahead of print. PMID: 39384964.
Jingyi Wang, Qiao Ye, Lidek Chou, Saijun Qiu, Xiangmin Xu, Zhongping Chen (2024). Miniaturized Head-Mount Doppler Optical Coherence Tomography Scope for Freely Moving Mouse. ACS Photonics. 2024 Aug 6;11(8):3381-3389. doi: 10.1021/acsphotonics.4c00856. PMID: 39184188; PMCID: PMC11342407.
Luiz M Oliveira, Alyssa Huff, Aguan Wei, Nicole C Miranda, Ginny Wu, Xiangmin Xu, Jan-Marino Ramirez (2024). Afferent and Efferent Connections of the Postinspiratory Complex (PiCo) Revealed by AAV and Monosynaptic Rabies Viral Tracing. J Comp Neurol. 2024 Nov;532(11):e25683. doi: 10.1002/cne.25683. PMID: 39494735.
Xiaoxiao Lin, Ali Ghafuri, Xiaojun Chen, Musab Kazmi, Douglas A Nitz, Xiangmin Xu (2024). Projection-specific circuits of retrosplenial cortex with differential contributions to spatial cognition. Mol Psychiatry. 2024 Nov 7. doi: 10.1038/s41380-024-02819-8. Epub ahead of print. PMID: 39511453.